Grey’s Anatomy: Izzie & Alex’s Relationship Timeline, Explained

Izzie Stevens (Katherine Heigl) and Alex Karev’s (Justin Chambers) complicated, long-term relationship is one of the most memorable love affairs in Grey’s Anatomy. At first, their romance is unexpected, as they don’t get along as interns at Seattle Grace Hospital, but the characters both come from broken homes and share a desire to become successful doctors. Grey’s Anatomy is known for featuring characters who fall in love as a result of the proximity of working together, but there’s something special and heartfelt about this particular couple. Their obstacles and arguments make up some of the most unforgettable moments in the long-running medical drama.