10 Great Movie Duos Who Only Worked Together Once

While some movie partnerships last for decades, other great acting duos have only appeared in a single film together. Some pairs of actors have such amazing chemistry that they work together on multiple projects, like Meg Ryan and Tom Hanks. In other cases, a movie duo can be so inherently watchable that they spark an entire franchise, like Mel Gibson and Danny Glover in Lethal Weapon. Whether there’s romantic chemistry, comedic chemistry, or something less tangible, the dynamic between two leads can often make a good movie into a great one.